Oxycodone has a boxed warning for its high potential for misuse and addiction. If you have a history of drug misuse, you may have an increased risk of this side effect while taking oxycodone. For more information, see the “Oxycodone and misuse” section above. Use of OXYCONTIN for an extended period of time during pregnancy can result in withdrawal in the neonate.
Oxycodone may cause side effects. Tell your doctor if any of these symptoms, are severe or do not go away:
For non-prescription products, read the label or package ingredients carefully. If you take too much oxycodone (known as an overdose), it’s important to get immediate medical attention. Overdose how addictive is oxycontin of opioid medicines can cause you to stop breathing. Using oxycodone with other medicines that can make you drowsy, such as sleeping tablets or other pain-relief medicines, can be dangerous.
What is oxycodone?
If concomitant use is necessary, consider dosage reduction of OXYCONTIN until stable drug effects are achieved. Evaluate patients at frequent intervals for respiratory depression and sedation. The concomitant use of OXYCONTIN and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of OXYCONTIN and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of OXYCONTIN is achieved [see WARNINGS AND PRECAUTIONS].
Other precautions
If symptoms do not go away or they get worse, talk to a doctor as you may need to try a different painkiller. Do not drive, cycle or use tools or machinery if you’re feeling dizzy. These side effects should wear off within a week or two as your body gets used to oxycodone. It might help to swallow your oxycodone (without chewing if it’s a tablet) just before or after a meal or snack. Ask your doctor about medicine to help prevent or treat constipation caused by oxycodone. Try to include more high-fibre foods in your diet such as fruits, vegetables and cereals.
What happens if I overdose?
- But if you have symptoms that are ongoing or bother you, talk with your doctor or pharmacist.
- Opioid analgesics, including OXYCONTIN, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions.
- Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times.
- So, someone taking a 30-mg dose of oxycodone may be at a higher risk of side effects than someone taking a 5-mg dose.
- Co-administration of OXYCONTIN (10 mg single dose) and the CYP3A4 inhibitor ketoconazole (200 mg BID) increased oxycodone AUC and Cmax by 170% and 100%, respectively [see DRUG INTERACTIONS].
Do not take any other medicines to treat the side effects of oxycodone without speaking to a pharmacist or doctor first. Noroxycodone exhibits very weak anti-nociceptive potency compared to oxycodone, however, it undergoes further oxidation to produce noroxymorphone, which is active at opioid receptors. Although noroxymorphone is an active metabolite and present at relatively high concentrations in circulation, it does not appear to cross the blood-brain barrier to a significant extent. Oxymorphone is present in the plasma only at low concentrations and undergoes further metabolism to form its glucuronide and noroxymorphone. Oxymorphone has been shown to be active and possessing analgesic activity but its contribution to analgesia following oxycodone administration is thought to be clinically insignificant.
- If switching from other oral oxycodone formulations to OXYCONTIN, administer one half of the patient’s total daily oral oxycodone dose as OXYCONTIN every 12 hours.
- Inform patients that they can visit /drugdisposal for a complete list of medicines recommended for disposal by flushing, as well as additional information on disposal of unused medicines.
- Examples of long-term side effects that are possible with oxycodone include seizures, adrenal conditions, and heart problems.
Additional data, including epidemiological data, when available, may provide further information on the impact of the current formulation of OXYCONTIN on the abuse liability of the drug. Accordingly, this section may be updated in the future as appropriate. The in vitro data demonstrate that OXYCONTIN has physicochemical properties expected to make abuse via injection difficult. The data from the clinical study, along with support from the in vitro data, also indicate that OXYCONTIN has physicochemical properties that are expected to reduce abuse via the intranasal route. However, abuse of OXYCONTIN by these routes, as well as by the oral route, is still possible. OXYCONTIN is formulated with inactive ingredients intended to make the tablet more difficult to manipulate for misuse and abuse.
Pregnancy and breastfeeding while taking oxycodone
Recent Comments